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骨髓增生异常综合征患者外周血CD4^＋CD25^＋调节性T细胞和Th3细胞变化 被引量：4

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摘要 研究表明，骨髓增生异常综合征（MDS）患者T细胞、B细胞、NK细胞和单核-巨噬细胞等固有免疫细胞和适应性免疫细胞存在质或量的异常^[1-2]。调节性T细胞是体内具有抑制免疫病理和自身免疫性疾病的CD4^＋T细胞，包括自然产生的CD4^＋CD25^＋调节性T细胞、分泌IL-10的Tr1细胞和分泌TGF—B的Th3细胞。近期研究发现FOXP3是自然产生的调节性T细胞更为特异性标志，
作者 王化泉 邵宗鸿 邢莉民 付蓉 刘鸿 吴玉红
机构地区 天津医科大学总医院血液肿瘤科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2008年第7期482-484,共3页 Chinese Journal of Hematology
基金 天津市科技支撑项目（07ZCGYSF00600） 天津市卫生局基金（06K242）
关键词 CD4^+CD25^+调节性T细胞 骨髓增生异常综合征 细胞变化 外周血 CD4^+T细胞 固有免疫细胞 单核-巨噬细胞 自身免疫性疾病
分类号 R686 [医药卫生—骨科学]
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参考文献8

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二级参考文献24

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共引文献7

同被引文献37

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  • 4Weber G F, Gaertner F C, Erl Wet al. IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphoryla- tion and induction of cell cycle arrest in the G2-M phase[J]. J Im- muno1,2006 ( 11 ) ; 177 : 8266-8272. 被引量：1
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引证文献4

二级引证文献12

中华血液学杂志
2008年 第7期

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