摘要
骨髓增生异常综合征(MDS)的本质是一种恶性克隆性骨髓髓系肿瘤性疾病。无论是基础研究还是临床研究都应紧紧抓住这个本质,不要被混杂因素所干扰。通过反映恶性本质的多个指标,如细胞发育异常、功能异常、染色体异常和基因突变等,综合诊断能提高诊断的准确性。MDS的治疗也需要考虑根除恶性克隆,改变疾病病程,促进正常造血,延长生命和改善生存质量。
The essence of myelodysplastic syndrome(MDS)is a malignant clonal bone marrow myeloid neoplasm.Both basic researches and clinical studies should firmly grasp this essence of MDS and should not be interferenced by confounding factors.Comprehensive diagnosis can improve the accuracy of MDS diagnosis by multiple indicators that reflect the malignant nature,such as cell dysplasia,function abnormalities,cytogenetic changes and gene mutations.The therapy of MDS should also eradicate the MDS clone,change the disease progression,stimulating normal hematopoiesis,prolong the survival and improve the quality of life.
作者
邵宗鸿
王化泉
SHAO Zong-hong;WANG Hua-quan(Department of Hematology,Tianjin Medical University General Hospital,Tianjin 300052,China)
出处
《天津医药》
CAS
北大核心
2018年第8期785-788,共4页
Tianjin Medical Journal
基金
国家自然科学基金资助项目(81170472
81570111)
