摘要
目的:利用固体分散技术制备洛伐他汀固体分散体,增加其溶出速率。方法:以不同比例的聚乙烯吡咯烷酮(PVP k30)、聚乙二醇6000(PEG 6000)为载体,采用溶剂法和熔融法制成洛伐他汀固体分散体,测定其溶出速率,并采用差示扫描量热(DSC)法、显微照相技术鉴别药物在固体分散体中的存在状态。结果:两种固体分散体均能提高洛伐他汀溶出速率,在药物载体比例大于1∶5时效果较好;洛伐他汀固体分散体中晶型消失,分散在载体中。载体为PVP K30所制固体分散体的溶出速率总体优于载体PEG 6000。结论:固体分散体能加速洛伐他汀溶出速率。
OBJECTIVE To improve in vitro release of lovastatin, the technology of solid dispersion was used to prepare lovastatin solid dispersion. METHODS Lovastatin solid dispersions were prepared respectively with solvent method and fusion method using PVP K30 and PEG 6000 as carriers. The solubility and in vitro dissolution characteristics of pure drug and solid dispersions in water were studied. DSC and photomicrography were used to determine the status of lovastatin solid dispersions. RESULTS The solubility and in vitro dissolution of two kinds of lovastatin solid dispersions were increased. The ratio of medicine and carriers was better when it was greater than 1 ： 5. Lovastatin was dispersed with carriers and the crystallographic form of lovastatin disappeared. The effects of PVP K30 as carrier of solid dispersions to increased the solubility and in vitro dissolution of lovastatin solid dispersions were better than PEG 6000. CONCLUSION The solid dispersions increase in vitro dissolution rate.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第12期970-972,共3页
Chinese Journal of Hospital Pharmacy
基金
河北省科技攻关资助项目(编号:05276101D-88
42761220)
河北省中医药管理局资助项目(批准号:05015)
河北大学人才引进项目(批准号:y2004039)
河北大学自然科学基金项目(编号:2005408)
