摘要
目的探讨缩宫素受体(OTR)在子宫腺肌症(AM)在、异位内膜中的分布及其与临床痛经之间的关系,研究OTR在疾病发病机制中的作用。方法采用免疫组织化学方法检测28例腺肌症病灶组织、28例在位内膜组织中OTR的表达,并和18例正常子宫内膜组织作对照。结果AM中OTR在腺肌症病灶中的表达(92.8%)高于在位子宫内膜中的表达(78.6%),P<0.05,并均高于正常子宫内膜(50%)。表达强度差异有统计学意义(P<0.05)。其表达在在位子宫内膜和正常子宫内膜中增殖期高于分泌期;而异位病灶则缺乏这样的差异性。重度痛经组比轻度痛经组OTR的表达增高。结论在AM中的在位及异位内膜中,OTR均有高表达,可能参与疾病的发生发展机制。OTR的表达与痛经症状相关,推测OTR系统与腺肌症相关症状痛经有关系。
Objective To investigate the distribution of Oxytocin receptor （OTR） in eutopic and ectopic endometrium in adenomyosis, and to explore the relationship between OTR and dysmenorrhea. Methods Samples of eutopic endometrium of adenomyosis （n = 28）, adenomyotic lesion （n= 28）, normal endometrium （n = 18） were collected. Expression of OTR in different tissue and cells during menstrual cycle was examined immunohistochemically. Results Adenornyotic lesion and eutopic endometrium showed more expression of OTR than in normal endometrium in adenomyosis （P〈0.05）. The expressive rate of OTR in eutopic endometrium was higher at the proliferation stage than at the secretion stage, while less periodical variation of OTR expression was found in the ectopic lesion in adenomyosis. The expression of OTR in ectopic lesion with adenomyosis was higher in the group with severe dysmenorrhea than mild dysmenorrhea. Conclusions The strong expression of OTR in ectopic and eutopic endometrium may be associated with the development and growth of adenomyosis. The relationship between OTR and dysmenorrhea suggests an involvement of the OTR system in developing pelvic pain and/or dysmenorrhea.
出处
《中国妇产科临床杂志》
2008年第4期262-264,291,I0001,共5页
Chinese Journal of Clinical Obstetrics and Gynecology
