摘要
目的探讨缩宫素受体(OTR)在子宫内膜异位症(EM)患者的异位内膜及在位子宫内膜组织中表达情况及与痛经的关系。方法应用蛋白免疫印迹法(Westernblotting)检测EM患者39例卵巢子宫内膜异位病灶,30例在位子宫内膜以及30例非EM患者的正常子宫内膜作为对照,比较不同组织中OTR蛋白的阳性表达率和表达强度的差异,以及与痛经的关系。结果OTR在EM组表达高于对照组(P<0.05),在EM组在位内膜增生期和分泌期的表达无显著性差异(P>0.05),OTR在EM组痛经者的表达高于非痛经者(P<0.05)。结论EM患者OTR的高表达可能参与了EM发病机制,而且可能与EM的痛经有关,对OTR的深入研究将为EM痛经的治疗提供新的方向。
Objective To investigate the expression of oxytocin receptors （OTR） in the ectopic and eutopic endometrium of women with endometriosis and its relationship with dysmenorrhea. Methods Tissue specimens from endometriosis patients, including 36 specimens of ovarian chocolate cyst and 34 eutopic endometrium, were collected, as well as normal endometrium from 30 patients with other gynecological diseases as controls. Extracted protein from the specimens was used to detect the expression of OTR by Western blotting. Results The expression of OTR in endometriosis was higher than normal controls （P〈0.05）. No difference of OTR expression was found between proliferative and secretory phases in endometriosis group （P〉0.05）. The expression of OTR in dysmenorrhea is higher than no dysmenorrhea in endometriosis group （P〈0.05）. Conclusions The overexpression of OTR in women with endometriosis may be one of the pathogenesis of dysmenorrhea, and it may be a new therapy target of dysmenorrhea in endometriosis in the further.
出处
《中国妇产科临床杂志》
2008年第2期111-113,123,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
北京市科学技术委员会2004~2007重点项目(H030930040230)资助
