摘要
富血小板血浆是自体源性、浓缩的含血小板的血浆,由其聚合而成的富血小板凝胶的应用是口腔颌面外科颌骨缺损修复的热点课题。目前,对于富血小板凝胶促进骨缺损修复的机制尚未完全阐明。普遍的观点认为聚合过程中血小板脱颗粒释放多种高浓度生长因子的联合作用刺激成骨,加速了骨修复。另外,富血小板凝胶的应用还存在一些尚待解决的问题。因此,富血小板凝胶在组织工程领域得到广泛应用尚需进一步的研究工作。相信随着研究的不断深入,富血小板凝胶必将广泛应用与骨组织工程。
Platelet-rich plasma is a volume of autogenous plasma with a high platelet concentration. Platelet-rich gel which is polymerized from platelet-rich plasma becomes a hot topic in the repairing of jaw bones in oral and dentofacial surgery. Presently, the mechanism of platelet-rich gel in enhancement of bone defect repair has not been clarified. Generally, we believed that the unifiation of blood platelet degranulation released many high-concentration growth factor during polymerization stimulated bone formation and accelerated bone repair. In addition, the application of platelet-rich gel has some problems. Thus, wide application of platelet-rich gel in tissue engineering deserves further studies. With the development, platelet-rich gel should be widely used in bone tissue engineering.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第23期4493-4496,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
