摘要
目的探讨老年冠心病患者血清β2微球蛋白(β2-MG)及C反应蛋白(CRP)水平与冠状动脉粥样硬化病变程度和范围的关系。方法选择162例行冠状动脉造影检查的患者,将其分为4组,用放射免疫分析法和免疫散射比浊法检测血清β2-MG、CRP水平,老年冠心病组按冠状动脉病变支数及狭窄程度进一步分组,比较各组血清β2-MG、CRP水平的差异及与冠状动脉病变程度的相关性。结果无论老年组或非老年组,冠心病患者血清β2-MG及CRP水平均明显高于健康对照组(P<0.01);在老年冠心病组中,冠状动脉病变支数越多,血清β2-MG、CRP水平越高,以3支病变组升高最明显,与1支病变组比较均有显著性差异(P<0.05);冠状动脉病变愈严重,血清β2-MG、CRP水平愈高,以3组升高最明显,与1组比较均有显著性差异(P<0.05);血清β2-MG、CRP水平与冠状动脉狭窄程度呈正相关,相关系数分别为0.512(P<0.01)和0.416(P<0.01)。结论老年冠心病患者血清β2-MG及CRP水平与冠状动脉硬化范围及严重程度均呈正相关关系,可能均是冠心病的独立危险因素。
Objective To investigate the correlation of serum C-reaction protein （CRP） and β2-microglobulin（β2- MG） with coronary stenosis degree in the old patients with coronary heart disease （CHD）. Methods 162 patients undergoing selecting coronary angiography were enrolled in this study. The patients were classified into four groups. The immunity transmission turbidity method was applied to measure the serum β2-MG and CRP concentration. The possible correlation of serum β2-MG and CRP level and coronary stenosis score were studied. Results Either the old group or non-old group, the levels of serum β2-MG and CRP were significantly different between the CHD group and the control group （ P 〈 0. 01 ）. In the old CHD group,the serum β2-MG and CRP level increased with the numbers or extents of coronary stenosis,and had positive association with coronary stenosis score （r =0. 512,P 〈0. 01 and r =0. 416,P 〈0. 01 ）. Conclusions In the old CHD group, a positive correlation exists between serum β2-MG or CRP level and the severity of coronary atherosclerosis. Serum β2-MG and CRP are independent risk factors in coronary artery disease.
出处
《实用老年医学》
CAS
2008年第3期182-184,187,共4页
Practical Geriatrics
