摘要
目的 探讨炎症因子与冠状动脉病变严重程度的关系。方法 选择经冠状动脉造影检查的患者共239例,分为非冠心病组、稳定性冠心病组、急性冠状动脉综合征组,检验3 组患者血浆C反应蛋白(CRP)、纤维蛋白原(FIB)水平。结果 急性冠脉综合征组、稳定性冠心病组、非冠心病组CRP分别为(21.06±13.52) mg/L、(10.17±7.37) mg/L和(4.14±4.33) mg/L,3组FIB分别为(3.35±1.14) g/L、(3.02±0.84) g/L和(2.60±0.74) g/L; 统计学分析表明,急性冠脉综合征组CRP和FIB水平明显高于稳定性冠心病组(P<0.01、P<0.05)和非冠心病组(均P<0.01),而稳定性冠心病组CRP、FIB水平又明显高于非冠心病组(均P<0.01);CRP、FIB在多因素回归分析中与冠状动脉病变程度之间仍有很强的正向相关性(均P<0.01)。结论 炎症因子CRP、FIB与冠状动脉病变严重程度密切相关,CRP、FIB可分别作为急性冠状动脉综合征的预测因子。
Objective To explore the relationship between the inflammation factors and the severity of the coronary artery lesions.Methods The study enrolled 239 patients who underwent a selective coronary angiography.All the patients were divided into three groups:the non-CHD group; the stable CHD group; the acute coronary artery syndromes group.The fasting blood samples were obtained to measure the level of C-response protein (CRP),fibrinogen (FIB).Result The plasma level of CRP in acute coronary artery syndromes group was ( 21.06± 13.52) mg/L,levels in stable CHD group and non-CHD group were ( 10.17± 7.37) mg/L and ( 4.14± 4.33) mg/L.The levels of FIB in acute coronary artery syndromes group,stable CHD group and non-CHD group were ( 3.35± 1.14) g/L,( 3.02± 0.84) g/L and ( 2.60± 0.74) g/L.The plasma levels of CRP,FIB in acute coronary artery syndromes group were significantly higher than those in stable CHD group and non-CHD group (P 0.01,P< 0.05).The average level of CRP,FIB were also significantly higher in stable CHD group than in non-CHD group (P< 0.01). A strong positive correlation existed between CRP level (P< 0.01),FIB level (P< 0.01) and coronary artery stenosis integrated scores.The multivariate regression analysis showed the severity of the coronary artery lesions was significantly associated with CRP (P< 0.01) and FIB (P< 0.05).Conclusion The inflammation factors,such as plasma CRP or FIB level,were related with the severity of the coronary artery lesions,they are important risk factors that related with coronary artery lesion progress,especially in the acute coronary artery syndromes.
出处
《临床荟萃》
CAS
北大核心
2005年第9期487-490,共4页
Clinical Focus
