摘要
目的研究丙种球蛋白应用时间对川崎病患儿退热时间及冠状动脉损伤的影响。方法选取2018年1月-2021年7月我院接诊的74例川崎病患儿为研究对象,采用随机数字表法分为对照组和观察组,各37例。对照组于病程10 d后给予丙种球蛋白治疗,观察组于病程1~10 d内给予丙种球蛋白治疗,比较两组临床疗效、临床症状消退时间、炎性水平[血小板计数(PCT)、白细胞计数(WBC)、C反应蛋白(CRP)]、并发症发生率以及不良反应发生率。结果观察组治疗总有效率为94.59%,高于对照组的83.78%,差异有统计学意义(P<0.05);观察组退热、皮疹、手足肿胀、颈部淋巴结肿大消退时间均短于对照组,差异有统计学意义(P<0.05);两组治疗后PCT、WBC、CRP均低于治疗前(P<0.05),但组间比较,差异无统计学意义(P>0.05);观察组冠状动脉扩张、冠状动脉瘤发生率均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在病程1~10 d给予丙种球蛋白治疗川崎病的效果理想,可缩短临床症状消退时间,减轻炎症反应,预防冠状动脉损伤的发生,且不良反应发生率较低,安全性较高。
Objective To study the effect of gamma globulin application time on antipyretic time and coronary artery injury in children with Kawasaki disease.Methods A total of 74 children with Kawasaki disease admitted to our hospital from January 2018 to July 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 37 cases in each group.The control group was treated with gamma globulin at 10 days after the course of disease,and the observation group was treated with gamma globulin at 1-10 days after the course of disease.The clinical efficacy,clinical symptom regression time,inflammatory level[platelet count(PCT),white blood cell count(WBC),C-reactive protein(CRP)],incidence of complications and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.59%,which was higher than 83.78%in the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,rash,hand and foot swelling and cervical lymph node enlargement in the observation group were shorter than those in the control group,differences being significant(P<0.05).After treatment,PCT,WBC and CRP in the two groups were lower than those before treatment(P<0.05),but there was no significant difference between the two groups(P>0.05).The incidence of coronary artery dilatation and coronary artery aneurysm in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion In the course of 1-10 days given gamma globulin treatment of Kawasaki disease effect is ideal,which can shorten the clinical symptoms subside time,reduce inflammation,prevent the occurrence of coronary artery injury,and the incidence of adverse reactions is low,with high safety.
作者
刘海珍
LIU Hai-zhen(Department of Pediatrics,Yudu County Maternal and Child Health Hospital,Yudu 342301,Jiangxi,China)
出处
《医学信息》
2022年第16期73-75,共3页
Journal of Medical Information
关键词
丙种球蛋白
川崎病
退热时间
冠状动脉损伤
Gamma globulin
Kawasaki disease
Antipyretic time
Coronary artery injury