摘要
背景与目的:机体组织中自然杀伤细胞和细胞毒T淋巴细胞是构成机体细胞免疫的主导成分,对肿瘤组织必然有影响。本研究探讨NK/T细胞在肺鳞癌组织中的浸润程度及对患者生存与预后的影响。方法:将CD8作为细胞毒T淋巴细胞(CTL)的标记物,CD56作为自然杀伤细胞(NK)的特异性标记物,应用免疫组织化学方法检测肿瘤组织中NK/T细胞的分布和浸润情况。结果:68例肺癌中,CTL无/轻度浸润的者39例,5年生存率为18%;显著浸润者29例,5年生存率为42%;NK细胞无/轻度浸润者46例,5年生存率为14%,显著浸润者22例,5年生存率为45%;NK/T无轻度浸润者48例,5年生存率为33%,均显著浸润的20例,5年生存率为54%。经Log-rank检验,NK/T显著浸润组5年生存率显著高于无/轻度浸润组,差异有显著性(x^2=18.62,P= 0.00)。结论:肺鳞癌组织中NK/T细胞显著浸润组的预后和生存时间明显优于轻度浸润组。其机制与机体细胞免疫有关。
Background and purpose： Both nature killer cells （NK） and cytoxic T lymphocytes in the body tissues of human are the dominant components of cellular immunity, This study was done to explore the degree of infiltration of NK/T in lung squamous cell carcinoma and its relation to patient survival and prognosis. Methods： CCD8 as the markers cytoxic T lymphocyte（CTL） and CD56 as the markers natural killer（NK） were stained immunohistochemically to detect the distribution and infiltration in the lung squamous cell carcinoma specimens. Results： In 39 of 68 lung neoplasm, whose CTL infiltration was zero or mild, the five-year survival rate was 18%, while in 29 with marked CTL infiltration, the five-year survival rate was 42%.In 46 of 68 lung neoplasm, whose NK infiltration was zero or mild, the five-year survival rate was 14%, while in 22 with marked NK infiltration, the five-year survival rate was 45%.In 48 of 68 lung neoplasm,both the NK and T cells were zero or mild, the five-year survival rate was 33%, while in 20 with marked NK and T cell infiltration,the five-year survival rate was 54%.The five-year survival difference among the patients with NK,T infiltration either marked or zero/mild infiltration were significant（x^2=18.62, P=0.00）. Conclusions： The degree of NK and T infiltration is positively correlated with the prognosis and survival time of lung squamous cell carcinoma patients.
出处
《中国癌症杂志》
CAS
CSCD
2008年第6期428-430,共3页
China Oncology
关键词
肺鳞癌
NK/T细胞
预后
lung squamous cell carcinoma
NK/T cell
prognosis
