摘要
目的:观察中晚期食管癌患者服用回生口服液联合自体细胞因子诱导的杀伤(CIK)细胞回输治疗后对机体细胞免疫功能的影响及临床疗效。方法:收集中晚期食管癌62例,随机分为对照组25例和观察组37例。2组患者均在相同化疗方案(PF)的基础上,对照组全程给予回生口服液每次10 ml,每天3次;观察组给予同剂量回生口服液联合CIK生物治疗。观察2组患者T细胞亚群的变化,并评价临床疗效。结果:观察组患者外周血CD8+T细胞较对照组下降(P<0.01),而CD3+、CD4+T细胞及CD4+/CD8+比值均较对照组升高(P<0.05～P<0.01)。观察组总有效率、生存质量评分及体重增加率与对照组差异均无统计学意义(P<0.05)。结论:回生口服液与自体CIK细胞回输联合使用能有效增进中晚期食管癌患者的细胞免疫功能,不增加不良反应的发生率,是安全有效的辅助治疗手段。
Objective：To observe the efficacy and cellular immune function of autologous cytokine induced killer（CIK） cells treatment plus Huisheng oral liquid in patients with advanced esophageal carcinoma. Methods：A total of 62 patients with advanced esophageal carcinoma were randomly assigned to two groups.All patients in both groups were received chemotherapy with 5-Fu plus DDP firstly.The patients in control group（25） were given Huisheng oral liquid 10 ml/three times per day,while others in observation group（37） were received Huisheng oral liquid,and autologous CIK cells treatment.The curative effect and changes of T-cell subgroup percentage were evaluated. Results：The mean percentages of CD8＋T-cell in observation group were lower than in control group;while CD3＋,CD4＋ T-cell and the ratio of CD4＋/CD8＋ were increased compared with control.No significant difference of total therapeutic effect,life quality score and weight was observed the two groups（P〈0.05）. Conclusions：Autologous CIK cells treatment plus Huisheng oral liquid in patients with advanced esophageal carcinoma could promote cellular immunity function,increase total therapeutic effect and life quality with no extra adverse reaction.It is a safe and effective assistance therapeutic tool.
出处
《蚌埠医学院学报》
CAS
2012年第9期1062-1063,1066,共3页
Journal of Bengbu Medical College
关键词
食管肿瘤
回生口服液
细胞因子诱导的杀伤细胞
过继免疫
esophageal neoplasms； Huisheng oral liquidcytokine； cytokine induced killer cells； adoptive immunotherapy
