摘要
目的观察复肝肽口服液(主要成分为新生牛肝活性肽)对大鼠四氯化碳(CCl4)慢性肝损伤的保护作用。方法制备大鼠CCl4慢性肝损伤模型,观察复肝肽口服液对慢性肝损伤大鼠红、白细胞数、血色素、血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总蛋白(TP)、白蛋白(ALB)、白球蛋白比例(A/G)的影响。结果与模型对照组比较,复肝肽3个剂量组大鼠的A/G值均明显升高,肝组织病变明显减轻,高剂量组ALT、AST明显降低。结论复肝肽口服液对慢性肝损伤有明显的保护作用。
Objective To observe the protective effect of Fugan peptide（FGP）, an oral preparation mainly consisting of newborn calf liver active peptide, on carbon tetrachloride-induced chronic liver injury. Methods Establish rat model of carbon tetrachloride-induced chronic liver injury, and observe the effect of FGP on the erythrocyte and leukocyte counts, the hematochrome, ALT, AST, total protein（TP）and albumin（ALB ）levels, as well as the ratio of albumin to globulin（A /G）of model rats. Results As compared with those untreated, the A / G of model rats treated with FGP at 3 dosages increased significantly, and the pathological lesion of liver tissue decreased significantly. However, the ALT and AST levels of model rats treated with FGP at a high dosage decreased significahtly. Conclusion FGP showed significantly protective effect on carbon tetrachloride-induced chronic liver injury.
出处
《中国生物制品学杂志》
CAS
CSCD
2008年第6期513-515,共3页
Chinese Journal of Biologicals
基金
(省部级课题)浙江省科学技术厅研究开发项目(F11028)
关键词
复肝肽口服液
新生牛肝活性肽
四氯化碳
慢性肝损伤
保护作用
Fugan peptide （FGP）
Newborn calf liver active peptide（NCLAP）
Carbon tetrachloride
Chronic liver injury
Protective effect
