摘要
目的探讨复肝肽对四氯化碳(CCl4)引起的小鼠化学性肝损伤的保护作用。方法将ICR小鼠随机分为5组,1个正常对照组、1个CCl4模型对照组和高、中、低剂量复肝肽+CCl4组(复肝肽的剂量分别为2.5、5.0、10.0ml/kg),每组10只。采用CCl4致小鼠化学性肝损伤模型,观察各组小鼠肝损伤情况。结果与CCl4模型对照组比较,中剂量复肝肽+CCl4组小鼠血清丙氨酸氨基转移酶(ALT)活力明显降低,差异有统计学意义(P<0.01);肝脏组织细胞变性、坏死程度明显减轻,差异有统计学意义(P<0.05)。与CCl4模型对照组比较,高剂量复肝肽+CCl4组小鼠肝脏组织细胞变性程度减轻,差异有统计学意义(P<0.05)。结论复肝肽对四氯化碳急性染毒致小鼠肝损伤的愈复有促进作用。
Objective To study the protective effect of FGP on liver damage in mice caused by carbon tetrachloride(CCl4).Methods Carbon tetrachloride was used to make the model of chemical liver damage.The mice were randomly divided into 5 groups,10 in each:FGP(10.0 ml/kg)+CCl4,FGP(5.0 ml/kg)+CCl4,FGP(2.5 ml/kg)+CCl4,CCl4(0.12%,10 ml/kg)and the control group.The mice were treated with FGP and CCl4 by gavage and intraperitoneal injection.The biochemical and pathological examinations were conducted to observe the liver d...
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2007年第4期219-220,共2页
Journal of Environment and Health
基金
浙江省科学技术厅研究开发项目(F13027)
关键词
环境污染
复肝肽
四氯化碳
急性毒性
肝损伤
Environmental pollution
FGP
Carbon tetrachloride
Acute toxicity
Liver damage
