摘要
对马来酸依索拉定的合成及其工艺进行了研究,在日本合成工艺的基础上,不再合成2,5-二氯苯腈.从合成2,4-二氨基-6-(2,5-二氯苯基)-1,3,5-三嗪开始实验,再合成马来酸依索拉定,将环化中的氢氧化钾改用i-Pr醇钾,提生碱性.经过70批次实验,并用液相色谱分析其含量,发现依索拉定的含量为99.5%,马来酸依索拉定的含量为98.5%,产品含量达到甚至超过日本药典标准.
The synthesis process of irsogladine maleate was studied based on the Japaness process but without the synthesis of 2,5-2 chlorine benzonitr/le. 2,4-D/amino-6- （2,5-dichloropherdy）- 1,3, 5-triazinemaleate were synthesized and then Irsogladine Maleate was sythesized using I-Pr Potassium instead of hydrogen oxidized potassium in wreath in order to lift alkalescence. Through 70 batches of experiments, liquid chromatography was used to analyze its content. The Irsogladine content is 99. 5%, Irsogladine Maleate content is 98. 5%. These two contents even exceed the standards of Japanese pharmacopoeia.
出处
《山东理工大学学报（自然科学版）》
CAS
2008年第3期64-67,共4页
Journal of Shandong University of Technology:Natural Science Edition
关键词
依索拉定
马来酸依索拉定
合成
液相色谱
含量
irsogladine
irsogladine maleate
synthesis
liquid chromatography
content
