摘要
目的：比较苄达赖氨酸两种片剂在家犬体内的药代动力学和相对生物利用度。方法：高效液相—荧光检测法。结果：家犬口服后，其体内的血药浓度—时间曲线符合一室开放模型。国产片和进口片的主要药动学参数分别为Ｃｍａｘ：１３．７８±１．８６ｍｇ·Ｌ－１和１４．０±１．５０ｍｇ·Ｌ－１；Ｔｍａｘ：６．２４±０．５９ｈ和６．３９±０．８２ｈ；ＡＵＣ：８８３．２８±１５６．３５ｍｇ·ｈ－１·Ｌ－１和９０５．１０±１７３．８０ｍｇ·ｈ－１·Ｌ－１。结论：国产苄达赖氨酸片剂对进口苄达赖氨酸片剂的相对生物利用度为９７．９９％±５．８７％，可以认为国产片与进口片生物等效。
AIM: To compare the pharmacokinetic and bioavailability between domestic and imported Bendazaclysine (BDZL) tablets in dogs. METHODS: BDZL was detected by HPLCfluorescence method. RESULTS: It was found that the characteristics of the plasma concentrationtime curve fit to onecompartment model after a single oral does of 100 mg·kg-1. Pharmacokinetic parameters of the two kinds of tablet were as follows: Cmax=1378±186 mg·L-1;140±150 mg·L-1;Tmax=624±059 h; 639±082 h, AUC=88328±15635 mg·h-1·L-1;90510±17386 mg·h-1·L-1. CONCLUSION: The relative bioavailability of domestic tablets was 9799%±587%, compared with imported tablets. It was showed that the two fomulations were bioequivalent.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1997年第6期515-517,共3页
Chinese Pharmacological Bulletin
基金
国家"八五"科技攻关资助
