摘要
目的 评价血清降钙素原（PCT）在社区获得性肺炎（CAP）诊断与病情判断中的价值。方法 2005年11月至2006年8月CAP患者96例（CAP组）。对照组30例。检测入院次日及第8天的血清PCT、CRP和血WBC。结果 （1）在CAP组及对照组中，分别取PCT、CRP、WBC的临界值为1．5μg／L、10mg／L、10×10^9／L做受试者工作特征（ROC）曲线，其曲线下面积分别为0．979、0．831、0．736。（2）PCT在细菌性肺炎、非典型病原体肺炎、病毒性肺炎中分别为（9．74±6．20）、（7．81±5．70）、（12．20±6．50）μg／L，三者之间差异无统计学意义。（3）PCT与CURB-65评分之间存在相关性（r=0．258，P=0．011）。PCT在轻、中、重症肺炎中存在差异。结论 血清PCT在CAP诊断中的敏感度和特异度均高于CRP、WBC，PCT与CAP病情严重程度有一定的相关性，提示PCT在CAP病情判断中具有实用价值。
Objective To evaluate the clinical value of procalcitonin （PCT） in the diagnosis and assessment of community-acquired pneumonia （CAP）. Methods Ninety-six patients with CAP（CAP group）who hospitalized during the period of November 2005 to August 2006 were admitted. Meanwhile, 30 people were taken as control group. The levels of PCT, CRP and WBC were detected on the next day and the 8th day of hospitalization. Results （ 1 ） The receiver operating characteristic （ ROC ）curve was made through setting the threshold value of PCT, CRP and WBC as 1.5 μg/L, 10 mg/L and 10 × 10^9/L respectively in CAP group and control group. The area undering ROC curve was 0.979, 0.831 and 0.736 respectively. （2） The mean value of PCT in the patients of bacterial pneumonia, atypical pathogen pneumonia and viral pneumoniawas （9.74：1= 6.20）, （7.81：1= 5.70 ） and （12.20：1= 6.50） μg/L respectively. There were no statistical differences in those patients. （ 3 ） There was correlation between PCT and CURB - 65 score （ r = 0.258, P = 0.011 ）. The value of serum PCT showed significant differences in the patients with mild pneumonia, moderate pneumonia and severe pneumonia. Conclusions Serum PCT has higher sensitivity and specificity than CRP and WBC in the diagnosis of CAP. There is correlation between PCT and the severity of CAP, so it indicates that PCT has a certain practical value in the judgement of the condition of CAP.
出处
《中国医师进修杂志（内科版）》
2008年第6期5-7,共3页
Chinese Journal of Postgraduates of Medicine
