摘要
采用病例-家系对照和随机病例-对照两种设计,分析了603例样本脂联素基因(Adiponectin,APM1)单核苷酸多态性(SNP)rs13061862(T45G)与湖北汉族人群2型糖尿病的相关性。在所有样本中,2型糖尿病病人的G等位基因及GG基因型频率显著高于正常人(G:42.0%比21.7%,P<0.001;GG:13.6%比4.5%,P=0.032);在180个病例-家系对照中,2型糖尿病患者的GG基因型频率显著高于对照组(GG:17.8%比5.6%,P=0.011);在423个随机病例-对照中,2型糖尿病患者GG基因型频率也显著高于对照组(GG:12.2%比3.9%,P=0.025);单因素Logistic回归分析显示,GG基因型是2型糖尿病的危险因子(OR=3.58,95%CI=1.70?7.54)。这些结果表明,脂联素基因SNPT45G多态性与湖北汉族人群2型糖尿病的发生发展相关,GG基因型是中国湖北汉族人2型糖尿病的遗传危险因素。
To investigate the association between the APMI SNP rs 13061862 and type 2 diabetes mellitus （T2DM）, a total of 603 Han subjects from Hubei Province were genotyped for the APMI SNP T45G. Both family-based casecontrol and unrelated case-control designs were used. The frequencies of the G allele and GG genotype for T2DM patients were significantly higher than those for controls （G： 42.0% vs. 21.7%, P〈0.001; GG： 13.6% vs. 4.5%, P= 0.032） in all subjects. The GG genotype was associated with higher risk of T2DM in family-based case-control groups （GG： 17.8% vs. 5.6%, P = 0.011）, while the G allele and GG genotype for T2DM patients were significantly higher than those for controls in the unrelated case-control groups （GG： 12.2% vs. 3.9%, P = 0.025）. Logistic regression analysis suggested that GG genotype was the genetic risk factors for T2DM （OR = 3.58, 95% CI=1.70-7.54）. In conclusion, the APMI SNP T45G is associated with T2DM risk, and the GG genotype may be a genetic risk factor of T2DM in Han population of Hubei Province.
出处
《遗传》
CAS
CSCD
北大核心
2008年第6期711-715,共5页
Hereditas（Beijing)
基金
国家自然科学基金(编号:30340068)
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关键词
2型糖尿病
脂联素基因
多态性
关联
type 2 diabetes mellitus
adiponectin gene
polymorphism
association
