摘要
目的探讨沙利度胺对胶原诱导性关节炎(collagen induced arthritis,CIA)大鼠肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)的影响。方法以CIA大鼠作为类风湿关节炎(rheumatoid arthritis,RA)的动物模型,将健康雄性Wistar大鼠76只分为正常对照组、CIA组、沙利度胺治疗组,通过比较三组大鼠足爪厚度及血清TNF-α水平之间的关系,探讨TNF-α在RA发病过程中的作用以及沙利度胺对CIA大鼠的治疗效果。结果血清TNF-α与CIA大鼠关节炎的肿胀程度密切相关,TNF-α浓度越高,关节的肿胀越严重。沙利度胺能够降低CIA大鼠血清TNF-α的浓度,改善CIA大鼠的关节肿胀情况。结论沙利度胺可通过降低大鼠血清TNF-α浓度进而改善CIA大鼠关节症状,有望应用于类风湿关节炎的治疗。
Objective To explore the effect of thalidomide on the expression of serum TNF-α in rats with collagen induced arthritis（CIA）. Methods Arthritis animal model was induced by collagen. Seventy-six healthy male wistar rats were divided into three groups,the control group, the model group and the thalidomide treatment group. Compare the relationship between serum TNF-α concentration and the paw thickness of model rats to investigate the possible mechanism of RA and the treatment effect of thalidomide on CIA rats. Results The more serious the arthritis is, the higher concentration of the serum TNF-α. There is a markedly positive correlation between arthritis and TNF-α concentration. Thalidomide can reduce the serum TNF-α concentration and meliorate the arthritis state of rats with CIA. Conclusion Thalidomide can meliorate the symptoms of arthritis through reducing the serum TNF-α concentration, it is hopeful to apply thalidomide in the treatment of RA patients.
出处
《河北医科大学学报》
CAS
2008年第3期357-360,共4页
Journal of Hebei Medical University
