摘要
目的探讨周围型肺癌SCT征象与血管内皮生长因子(VEGF)、E钙黏附蛋白(E-cad)表达的关系。方法对58例周围型肺癌患者术前行螺旋CT(SCT)扫描,术后标本采用免疫组化SP法检测肿瘤组织中E-cad和VEGF蛋白表达。结果周围型肺癌中,胸膜侵犯、淋巴转移及TNM分期SCT诊断准确率分别为86.67%、88.24%和81.25%。肺癌E-cad的异常表达与肿瘤的大小、棘突征、胸膜侵犯及淋巴转移明显相关;VEGF的表达与周围型肺癌的毛刺征、棘突征、空洞征、胸膜侵犯、淋巴转移明显相关。结论SCT可清晰显示周围型肺癌的各种征象,较准确地反映肿瘤浸润转移的病理学和生物学特性。
Objective To investigate the correlation between spiral-CT （SCT） features and expressions of VEGF, E- cad in peripheral pulmonary carcinoma （PPC）. Methods 58 cases with pulmonary carcinoma confirmed were performed SCT within one week before surgery. Expressions of VEGF, E-cad of pulmonary carcinoma were examined with SP immunohistochemical technique. Results The rate of pleural invasion, lymph node metastasis and the TNM of tumor by SCT diagnosis was 86.67%, 88.24% and 81.25%. The abnormal expression of E-cad was associated with the size of tumor, pleural invasion and lymph node metastasis. The expressions of VEGF were closely associated with spiculation sign, spine sign, pleural invasion, lymph metastasis. Conclusion SCT can clearly show all kinds of signs of PPC and accurately reveal the pathological and biological characteristics of invasion and metastasis in PPC.
出处
《山东医药》
CAS
北大核心
2008年第14期8-10,共3页
Shandong Medical Journal
基金
国家自然科学基金资助项目(30571552)
