摘要
目的观察短期全身应用甲基强的松龙在慢性阻塞性肺疾病急性加重期（AECOPD）的疗效。方法将67例AECOPD患者随机分为治疗组和对照组，对照组给予吸氧、抗感染、平喘及对症支持治疗。治疗组除上述治疗外，还静滴甲基强的松龙40～80mg／d，疗程3～5d，比较两组治疗前及治疗3d后肺功能（FEVl）及动脉血气（Pa02、PaCO2）的改善程度。结果治疗3d后治疗组和对照组肺功能（FEVl）及动脉血气（PaO2、PaCO2）均有改善，但治疗组较对照组改善明显（P〈0．05），且无1例出现不良反应。结论短期应用甲基强的松龙可明显改善AE—COPD的肺功能，缓解临床症状。
Objective To observe the effect of shortterm systemic application of methylprednisolone on patients with acute exacerbation of COPD. Methods 67 patients with c with acute exacerbation of COPD were randomly divided into treatment and control groups. All the cases were treated with the same routine therapy, and the treated group with intravenous methylprednisolone with the doses of 40 - 80mg/d for3 - 5d; the degree of improvement in arterial blood gas（ PaO2, PaCO2 ）, lung function （ FEV1 ） were compared. Results Compared with the control group, the PaO2, PaCO2, FEVl in treatment group were improved significantly after .5 days treatment（P 〈0.0.5）. There is no case of adverse reactions. Cenlusion Short- term sys- temic application of methylprednisolone in patients with acute exacerbation of COPD is safe and effective.
出处
《湖北民族学院学报（医学版）》
2008年第1期43-44,共2页
Journal of Hubei Minzu University(Medical Edition)
关键词
甲基强的松龙
肺疾病
慢性阻塞性
急性加重期
Methylprednisolone
Pulmonary Disease
Chronic Obstructive
Acute Exacerbation
