摘要
目的:探讨AnnexinⅠ蛋白在前列腺癌组织中的表达及其与前列腺癌发生、发展、转移及预后的关系。方法:回顾性分析110例前列腺癌及40例前列腺增生组织中AnnexinⅠ蛋白的表达与前列腺癌Gleason分级、年龄、临床分期、转移及预后的相关性。结果:前列腺癌患者的AnnexinⅠ表达水平显著地低于良性前列腺增生症患者(P<0.05);AnnexinⅠ在低分化癌中表达较高,与高、中分化癌相比有显著性差异(P<0.05);而高、中分化癌之间AnnexinⅠ表达均较低,两者之间无显著性差异(P>0.05)。前列腺癌AnnexinⅠ蛋白表达与年龄无关,而与临床分期、淋巴结转移及预后有关(P<0.05)。结论:AnnexinⅠ蛋白表达下调与前列腺癌发生发展和预后密切相关,可作为反映前列腺癌生物学行为和判断预后的生物标记物。
Objective： To investigate the relationship between the expression ofannexin Ⅰ and tumorigensis, progression, metastasis and prognosis in prostate carcinomas. Methods： 110 cases of prostate carcinoma tissues and 40 cases of prostate hyperplasia tissues were examined by immunohistochemical staining. And the relationship between the expression of Annexin Ⅰ and Gleason grade, age, clinical stage, metastasis, and prognosis were analyzed by retrospective analysis. Results： The expression level of annexin Ⅰ in prostate carcinomas were significant lower than that in prostate hyperplasia（p〈0.05 ）. There were higher level of annexin Ⅰ in poorly differentiated prostate carcinomas than that in well or moderately differentiated prostate carcinomas （p〈0.05）. Annexin Ⅰ expression was not significantly different between well differentiated and moderately differentiated prostate carcinomas（p〉0.05 ）. The expression level of annexin Ⅰ were significantly correlated with clinical stage,metastasis and prognosis（p〈0.05 ）, but not ages. Conclusion： Down-regulation of annexin Ⅰ is closely related with the tumorigensis, progression, and prognosis of prostate carcinomas, Which maybe serves as a useful biomarker of biological behavior and prognosis in prostate carcinomas.
出处
《现代生物医学进展》
CAS
2008年第5期910-912,共3页
Progress in Modern Biomedicine
