摘要
目的研究中期因子(MK)在胃癌患者术前、术后不同时期外周血中含量的变化及其临床意义。方法用酶联免疫吸附实验对20例健康体检者(对照组)及45例胃癌患者术前第1d、术后第7d外周血进行MK含量的检测。结果胃癌病人术前血清MK的吸光度(OD值)平均值为(0.559±0.136),术后血清MK的吸光度平均值为(0.369±0.119),对照组为(0.280±0.097),术前血清MK吸光度均高于术后血清吸光度及对照组血清吸光度,差异有统计学意义(P<0.001)。Ⅰ～Ⅱ期胃癌中的血清MK的吸光度明显低于Ⅲ～Ⅳ期胃癌(P<0.001)。结论胃癌病人血清MK明显升高,MK不仅是一种肿瘤标志物,还可能作为胃癌侵袭性及预后评价的指标。
Objective To investigate the clinical significance of midkine （MK） levels in serum of patients with gastric carcinomas before and after operationMethods The levels of Serum MK were detected using enzyme-linked immunosorbent assay （ELISA）in 20 healthy cases and 45 patients with gastric carcinomas when the day before operation and the seventh-day after operation.Results The optical density （O.D.）of MK in serum of gastric carcinomas patients before operation were significantly higher than those after operation and those in healthy controls （P〈0.001）.The optical density of MK in patients with gastric carcinomas in stage Ⅰ～Ⅱ was significantly lower than that in stage Ⅲ～Ⅳ（P〈0.001）.Conclusion That the levels of serum MK were markedly increased in patients with gastric carcinomas,which may serve as a tumor marker and an evaluation for invasion and prognosis after operation.
出处
《江西医药》
CAS
2008年第3期192-194,共3页
Jiangxi Medical Journal
关键词
胃癌
血清MK的吸光度
术前
术后
gastric carcinoma
the optical density of the serum MK
before and after opration
