摘要
目的：确定葛心通缓释片的体外释放度的测定方法及其体外释放度。方法：采用转篮法,考察不同溶出介质中葛根素的释放情况,选择合适的溶出介质;确定最佳的转速,采用HPLC法测定葛心通缓释片的累积释放度,确定制剂的体外药物释放度。结果：以蒸馏水为溶出介质,葛心通缓释片在100 r/min的条件下,在2、6、12h的释放度分别为30%-40%、65%-75%、90%-98%。结论：葛心通缓释片体外释放度符合药典要求,具有良好的缓释行为。
Objective： To establish the method and the in vitro release rate of gexintong sustained tablets. Methods： A reverse phase HPLC method was developed to determine the release rate of the preparation. Dissolution media and the rotating speed were optimized by comparing the release of puerarin. Result： The release rate of the preparation at 2.6.12h is30% - 40% .65% - 75% .90% - 98% in distilled water at the rotating speed 100r/min. Conclusion ： In vitro release rate of Gexintong sustained released tablets is appropriate and meet Chinese pharmacopeia requirments.
出处
《辽宁中医杂志》
CAS
北大核心
2008年第3期430-431,共2页
Liaoning Journal of Traditional Chinese Medicine
关键词
缓释
葛根素
体外释放度
Sustained release
puerarin
in vitro release rate
