摘要
目的:制备盐酸青藤碱缓释微丸,并对其体外释药行为进行研究。方法:采用离心造粒技术制备盐酸青藤碱素丸,在流化床内采用丙烯酸树脂水分散体对其包衣,制备盐酸青藤碱缓释微丸。对包衣材料种类、配比及用量进行选择,对包衣微丸体外释药机理进行研究。结果:包衣材料Eudragit NE30D增重5%时,包衣微丸在水中呈现良好的缓释效果,体外释药过程基本符合Higuchi方程:Y=0.093 8+0.084 6t(r=0.996 5)。结论:采用离心造粒技术和丙烯酸树脂流化床包衣,成功地制备了盐酸青藤碱缓释微丸,其体外释药缓慢、平稳。
OBJECTIVE To prepare the sinomenine hydrochloride sustained-release pellets and study its in vitro drug release. METHODS Uncoated pellets were prepared in a centrifugal granulator by Powder-laying method. Eudragit dispersions were coated as a sustained-release layer in a fluid-bed equipment. The release mechanism of the drug from the pellets was studied. RESULTS The main factors affecting the release rate were the type and the amount of the coating material applied. Release of the drug from pellets was in accordance with Higuchi equation： Y = 0.093 8 ＋ 0.084 6t （r= 0. 996 5）. CONCLUSION The method and the formulation are successful in providing slow and steady release of sinomenine hydrochloride from sustained- release pellets.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第5期360-362,共3页
Chinese Journal of Hospital Pharmacy
关键词
盐酸青藤碱
缓释微丸
丙烯酸树脂
离心造粒
流化床
sinomenine hydrochloride
sustained-release pellets
eudragit
centrifugal granulation
fluid-bed
