摘要
目的：分析孤独症儿童局部脑灌注变化特点.方法：对72例临床诊断为孤独症的儿童应用单光子发射型计算机断层显像仪（SPECT）进行局部脑灌注显像,观察孤独症儿童局部脑血流（rCBF）变化情况.结果：在72例中,有79%患儿存在rCBF降低,其中74%病灶位于海马回、颞叶、顶枕叶、扣带回等边缘系统.3-6岁患儿额叶rCBF降低发生率比小于3岁和大于6岁患者发生率高（P〈0.05）.两侧rCBF降低发生率及病灶部位构成比例,无统计学差异.结论：孤独症患儿大多数存在海马回、颞叶等边缘系统的rCBF降低,3-6岁阶段可能存在暂时的大脑额叶rCBF降低.
AIM： To analyze the characters of the cerebral perfusion function in children with autism. METHODS： The regional cerebral blood flow （rCBF） imaging was performed on 72 autistic children with the single photon emission computed tomography （SPECT） , and the characters of cerebral perfusion function variation were analyzed. RESULTS： There were 79% autistic children with the lower rCBF focuses in 72 cases. 74% focuses were located in the cerebral limbic system such as hippoeampal gyrus, temporal lobe, parietal and occipital lobe, cingulate gyrus. The incidence rate of lower rCBF at frontal lobe of 3 - 6 year-old children with autism was markedly higher than those of 〈 3 and 〉 6 year-old children （P 〈 0. 05 ）. There was no significant difference in the incidence of lower rCBF between two-side hemispheres （P 〉 0. 05 ）. CONCLUSION： Most autistic children have the lower rCBF at cerebral limbic system, and the temporary malfunction of frontal lobe may happen in autistic children of 3 -6 years old.
出处
《第四军医大学学报》
北大核心
2008年第5期450-452,共3页
Journal of the Fourth Military Medical University
关键词
孤独症
儿童
局部脑血流
脑血管循环
autism
child
regional cerebral blood flow
cerebrovascular circulation
