摘要
儿童孤独症(CA)是一种难治性疾病。本文综述其脑影像学显像特点。脑血流灌注显像示CA患儿左侧(或双侧)额叶前部、左侧Broca区和左侧Wernicke区局部脑血流灌注和功能异常;葡萄糖代谢显像示额叶、颞叶及丘脑等局部脑葡萄糖代谢率(LCMRGlu)减低;多巴胺转运体(DAT)显像示CA患儿脑内DAT水平高于对照组,但两者分布无差异;5-羟色胺转运体(SERT)显像示SERT再摄取能力在大脑内侧额叶皮质下降;5-HT2受体显像提示,5-HT2受体密度减低。CA患儿脑内5-HT合成能力减低;fMRI示CA患儿皮层-边缘系统神经通路异常,脑内多个部位白质纤维的完整性受到破坏,脑内NAA浓度减低、NAA/Cr比值降低等。
Childhood autism（CA） is a kind of refractoriness disease.The characteristics of brain imaging of CA were reviewed in this article.Cerebral blood flow perfusion tomography revealed abnormalities of regional cerebral blood flow and function in left（or both） frontal lobes,left Broca area and left Wernicke area.Glucose metabolism imaging showed an decrease of local cerebral metabolic rate of glucose（LCMRGlu） in the frontal lobe,temporal lobe and thalamus.DAT SPECT imaging indicated the dopamine transporter（DAT） level in the brains of the children with autism was higher compared with that in normal controls,but there was no difference in distribution.The serotonin transporter（SERT） imaging proved declined reuptake capacity in medial prefrontal cortex.Reduced 5-HT2 receptor density and impaired synthetical capacity of 5-HT were observed in autistic children.fMRI showed neural pathway abnormalities in cortex-limbic system,and illustrated the white matter integrity disconnected in many brain regions in children with autism,significant reductions in NAA and less ratio of NAA/Cr,and so on.
出处
《中国医学影像技术》
CSCD
北大核心
2011年第6期1303-1306,共4页
Chinese Journal of Medical Imaging Technology
关键词
孤独性障碍
诊断显像
儿童
Autistic disorder
Diagnostic imaging
Child
