摘要
目的:探讨孤独症患儿脑功能影像学的改变及其行为表现的关系。方法:对39例临床诊断为孤独症的儿童采用单光子发射型计算机断层显像仪(SPECT)进行局部脑灌注显像,观察孤独症儿童局部脑血流(rCBF)变化的情况,并采用儿童孤独症评定量表(CARS),分析比较其SPECT改变与量表总分和各单项得分的关系。结果:在39例中,有69.23%患儿存在rCBF降低,其中76%病灶位于颞叶和额叶。经相关分析,孤独症的各项目得分与部分脑区血流灌注减少有关。结论:大脑局部血流灌注降低与孤独症的发生及其表现有关。
Objective ： To explore the changes of imaging in brain functional and the correlation between these and clinic behavior in child autism. Methods： Thirty nine cases of autistic children using single photon emission computed topography imaging instrument （ SPECT ） local brain perfusion imaging, observation of regional cerebral blood flow （ rCBF ） changes, and use the Childhood Autism Rating Scale （ CARS ）, analyze the correlation be- tween the changes of SPECT and total scores and each signal scores of CARS. Results： 69. 23% autism children had lower rCBF, of which 76% lesions located in the temporal and frontal lobes. Through correlation analysis, the scores of each items of autism and regional cerebral blood flow reduction. Conclusion： the decrease of brain re- gional blood flow perfusion relevant with autism.
出处
《新医学》
2012年第12期850-854,共5页
Journal of New Medicine
