摘要
以一锅法研究了对氯苯酚与2,4-二氯苯乙酮间的Ullmann反应,对传统的两步法进行了改进。较系统地考察了反应物配比、催化剂、反应溶剂、碱及反应时间对反应的影响。研究结果表明,采用CuCl为催化剂,对氯苯酚与2,4-二氯苯乙酮的配比为1∶1.2(摩尔比),异丙苯为溶剂,K2CO3为碱,160℃下反应18 h为最佳条件,产率为78%。
The ullmann reaction of 4-ehlorophenol and 1-（2,4-diehloro-phenyl） -ethanon by one-pot was researched, which was more efficient and convenient compared with the traditional two-step method. The effect of the ratio of reactants to catalyst, the reaction solvents, alkaline and time on the reaction was investigated. The results showed that the optimal conditions were as followed： the ratio of reactants was 1 ： 1.2, CuCl as catalyst, isopropyl benzene as solvent, K2CO3 as alkaline, and temperature was 160 ℃ for 18 h,then the yield was 78%.
出处
《化工技术与开发》
CAS
2008年第2期9-11,38,共4页
Technology & Development of Chemical Industry
