摘要
研究杀菌剂苯醚甲环唑的制备.以2,4-二氯苯乙酮为起始原料,经醚化、溴化、缩酮化、亲核取代4步反应制得苯醚甲环唑.醚化反应采用一步法,酚的成盐与醚化反应同时进行,收率可达93.6%.在醚化产物(Ⅲ)的甲基上进行溴化反应得到溴化产物(Ⅳ),产率89.1%.化合物(Ⅳ)与1,2-丙二醇反应得到缩酮产物(Ⅴ),产率89.6%.化合物(Ⅴ)与1H-1,2,4-三氮唑进行亲核取代反应得到目标产物(Ⅵ),产率69.0%.对各步反应的工艺进行了改进,总收率高达51.6%.
The preparation of fungicide difenoconazole is studied. Difenoconazole was prepared from 2, 4-dichloroacetophenone followed by etherification, bromination, ketal reaction and nucleophilic substitution. Phenol salt formation and etherification were finished in one step pathway to give （Ⅲ ） in 93.6 % yield. Bromination of （ Ⅲ） with bromine gave （ Ⅳ ） in 89.1% yield. The compound （ Ⅴ ） was obtained by ketal reaction of （ Ⅳ ） with 1, 2-propylene glycol in 89.6% yield. The title compound （Ⅵ） was then prepared by nucleophilic substitution of （Ⅴ） with 1H-1, 2, 4-triazole in 69.0% yield. The procedure was eventually improved and the total yield reached 51.6%.
出处
《北京理工大学学报》
EI
CAS
CSCD
北大核心
2006年第4期365-368,共4页
Transactions of Beijing Institute of Technology
关键词
苯醚甲环唑
杀菌剂
醚化
difenoconazole
fungicide
etherification
