摘要
目的探讨白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子(TNF-α)与C-反应蛋白(CRP)对早产胎膜早破孕妇患绒毛膜羊膜炎的监测价值。方法对86例早产胎膜早破孕妇(58例有绒毛膜羊膜炎)血中IL-6、IL-8、TNF-α和CRP进行检测,并以正常孕妇20例作为对照组。结果58例绒毛膜羊膜炎患者血清IL-6,IL-8和CRP均明显高于非绒毛膜羊膜炎者和对照组,差异有统计学意义(P<0.01);绒毛膜羊膜炎患者血清TNF-α水平也升高,但无统计学意义(P>0.05);绒毛膜羊膜炎患者血IL-8,CRP,TNF-α水平与IL-6含量呈正相关。结论孕妇血中IL-6,IL-8和CRP的联合测定,可作为监测绒毛膜羊膜炎的重要指标;血TNF-α的测定有一定的辅助作用。
Objective To explore the value of interleukin - 6（IL- 6） ,interleukin - 8（IL- 8） ,tumor necrosis factor（TNF - α） and C - reactive protein（CRP） from maternal serum in monitoring patients with ehofioamninitis and premature rupture of membranes. Methods The levels of IL- 6,IL- 8 TNF- αand CRP in maternal blood in 86 eases of premature rupture of fetal membranes（58 cases of chorioamninitis） were detected, 20 normal pregnant women were taken as controls. Results In patients with ehofioamninifis the levels of IL - 6, IL - 8 and CRP in maternal blood were significantly higher than that of normal pregnant women and patients with non - ehofioamnionitis（ P 〈 0.01） .The level of TNF - α in patients＇ serum with chorioamnionitis was higher than that of normal pregnant women and non- chorioamnionitis,but there were negative differences（ P 〉 0.05） ;In ehofioamnionitis the relationship between the levels of IL - 8, CRP, TNF - αof blood and IL - 6 is positively correlated. Conclusion The levels of IL - 6,1L- 8 and CRP in maternal serum are a significant marker for chorioamnionitis. The determination of level of TNF - αin bloodis helpful for monitoring chroioamnionitis.
出处
《中国热带医学》
CAS
2008年第1期19-20,共2页
China Tropical Medicine
