摘要
目的探讨白细胞介素６（ＩＬ６）和肿瘤坏死因子α（ＴＮＦα）水平在胎膜早破孕妇和绒毛羊膜炎患者母血和羊水中的变化及其临床意义。方法采用放射免疫法和酶联免疫吸附试验，测定４６例胎膜早破孕妇（胎膜早破组）和２０例正常足月孕妇（对照组）母血和羊水中ＩＬ６、ＴＮＦα水平，同时进行胎膜病理检查。结果观察组母血中ＩＬ６和羊水中ＩＬ６、ＴＮＦα明显高于对照组，差异有极显著性（Ｐ＜０．０１）；破膜时间与母血中ＩＬ６，羊水中ＩＬ６、ＴＮＦα水平有明显关系，随着破膜时间延长其含量增高；１２例绒毛羊膜炎患者其母血和羊水中ＩＬ６、ＴＮＦα水平均明显高于非绒毛羊膜炎孕妇，差异有显著性（Ｐ＜０．０１～Ｐ＜０．０５）。结论母血和羊水中ＩＬ６、ＴＮＦα水平变化可作为绒毛羊膜炎的诊断指标之一。
Objective To study the change and clinical significance of maternal serum and amniotic fluid interleukin 6 (IL 6) and tumor necrosis factor α (TNF α) levels in patients with chorioamnionitis and premature rupture of membrane (PROM). Methods Twenty normal term pregnant women as control, and fourty six women with PROM were enrolled for study. Maternal serum and amniotic fluid IL 6, TNF α levels were measured by radioimmunoassay and enzyme labeled immunosorbent assay (ELISA). Chorioamnionitis was diagnosed histologically. Results The maternal serum IL 6 levels and amniotic fluid IL 6, TNF α levels were higher in PROM group than that of control ( P <0.01). There was significant positive correlation between maternal IL 6, amniotic fluid IL 6, TNF α levels and the duration from rupture of membrane, (the longer was time, the higher were the maternal IL 6 and the amniotic fluid IL 6. TNF α). There were 12 cases with chorioamnionitis in patients with PROM and their maternal and amnotic fluid IL 6, TNF α levels were higher than that of non chorioamnionitis ( P <0.01～ 0.05). Conclusion IL 6 and TNF α levels in maternal serum and amniotic fluid are valuable clinical indices for identification of chorioamnionitis in patients with PROM.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1998年第6期328-330,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
胎膜早破
白细胞介素6
肿瘤坏死因子
羊水
Fetal membranes, premature rupture Interleukin 6 Tumor necrosis factor
