摘要
目的:探讨血管紧张素转换酶(ACE)基因I/D多态性和载脂蛋白E(ApoE)基因多态性与脑梗死(CI)的关系。方法:应用聚合酶链式反应-限制性片断长度多态性(PCR-RFLP)技术检测78名CI患者和90名健康对照者的ACE和ApoE基因型和等位基因频率并进行比较和分析。结果:CI组E3/4基因型频率(23.1%)及ε4频率(14.7%)显著高于对照组(7.8%,5.0%),而E3/3基因型频率(56.4%)以及ε3的频率(75.6%)显著低于对照组(78.9%,88.3%)。P值均<0.05;在同时携带ApoE E3/4基因型和ACE DD基因型的个体患CI的危险度为3.706,P<0.05。结论:ApoE基因多态性可能是CI发病的遗传因素;与ACEDD基因型间具有协同致CI作用。
Objective： To identify an interaction between angiotensin I - converting enzyme （ACE） gene and apoliporotein E （ApoE） gene polymorphisms on the risk of cereral infarction. Methods： ACE genotypes and ApoE genotypes were investigated with the method of PCR- RLFP in 78 patients with cerebral infarction（CI） and 90 agematched population controls. Results： ApoE gene polymorphism revealed significant difference of genotype and allelic distribution in CI patients and controls . The odds ratio for CI associated with the ACE DD genotype and ApoE E3/4 genotype was 3. 706, P 〈 0.05. Conclusions： The polymorphism of ApoE is related to the incidence of CI; There were synergistic effects of ACE and ApoE gene polymorphisms on the risk of CI.
出处
《内蒙古医学杂志》
2008年第1期4-6,共3页
Inner Mongolia Medical Journal
基金
包头市医药卫生基金项目(BK2003121)(ACE基因多态性与脑血管病的关系)
包头市科技计划项目(2005G30020-34)(ApoE基因多态性与脑血管病的关系)
