摘要
文章比较研究了鲟鱼和鲨鱼硫酸软骨素的红外光谱特性。结果表明,鲟鱼硫酸软骨素在1376,1344,1310,1157,883和856cm-1等波数上呈现出特有的振动峰,进一步的分析表明,鲨鱼硫酸软骨素中只有6-硫酸基团,而鲟鱼硫酸软骨素中则同时存在有6-硫酸基团和4-硫酸基团,这一特点表明鲟鱼硫酸软骨素在降低药物的毒性,有效杀伤癌细胞的方面可能具有较高的生物活性;两种硫酸软骨素的红外光谱总体基本相似,都含有乙酰氨基、羧基、硫酸基、糖环等官能团的振动峰,但鲟鱼硫酸软骨素的乙酰氨基的N—H变角振动峰的波数较高,1415cm-1处的羧基振动峰也明显强于鲨鱼硫酸软骨素,进一步化学分析显示,鲟鱼硫酸软骨素中的葡萄糖醛酸含量较高,推测鲟鱼硫酸软骨素很可能是一种较好的医用骨骼修复材料。
The characteristics of the Fourier-transform infrared spectra of sturgeon and shark chondroitin sulfates （CHSs） were comparatively studied. The results show that sturgeon CHS exhibits special vibrations at the wavenumbers of 1 376, 1 344, 1 310, 1 157, 883 and 856 cm^-1. Further analysis shows that shark CHS contains 6-sulfated-CHS, while sturgeon CHS contains 4, 6-disulfated CHS, indicating that sturgeon CHS could have higher biological activities in decreasing the toxicity of medicine and in killing cancer cells. In general, the two kinds of CHSs have similar infrared spectra and groups of acylamino, carboxyl, sulfate, and saccharide ring. But the N—H variable-angle vibration of acylamino group of sturgeon CHS occurs at the higher wavenumber, and the vibration intensity of carboxyl group at 1 415 cm^-1 is also stronger than that of shark CHS. Chemical analysis shows that sturgeon CHS has a higher content of glucuronic acid, suggesting that it probably could be a better kind of medical materials for the bone mineralization.
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2008年第1期106-109,共4页
Spectroscopy and Spectral Analysis
基金
厦门市科技计划项目(3502Z20031048)资助
关键词
鲟鱼
鲨鱼
硫酸软骨素
红外光谱
Sturgeon
Shark
Chondroitin sulfate
Infrared spectrum
