摘要
肝癌的自然病程至今未能确定，其主要原因是难以观察到在整个病程中均不接受任何抗癌治疗的病例。作者采用回顾性调查与随访的方法，观察到9例肝癌患者从1～2cm病灶发展至死亡也未接受过任何抗癌治疗的自然病程。发现9例患者的病程期为32．67±9．03月，肝癌从1～10cm到出现临床症状的时间为26±6．40月，出现症状到死亡的时间为5．56±4．16月，肿瘤的体积倍增时间为3．18±1．18月，据此推算肝癌从1cm增至10cm约需31．69月。表明在肝癌的病程中无症状期的时间远长于有症状期的时间，传统认为肝癌病程只有6个月左右的观念应予更新。肝癌自然病程的上述特点，提示临床评价大肝癌与小肝癌的治疗效果时应考虑到肝癌的病程因素。
The main cause of the natural course of liver cancer is still unknown is that thepatients who did not receive any treatment for cancer during the course is very rare. By themethods of retrospective and follow-up suvey, the natural course of nine patients who didnot receive any treatment for cancer in the whole course was observed by author. The naturalcourse of 9 patients was 32. 67± 9.03 months. The time from asymptomatic (tumor diameterof 1～2cm) to sympaomatic stage and from clinical stage to death was 26± 6. 4 and 5. 56 ±4. 16 months respectively. Tumor doubling time was 3. 18± 1. 18 months. 31. 69 months wasrequired for tumor trowth from 1cm to 10cm. These results indicated that the asymptomaticstage is much longer than the symptomatic stage in the natural course of liver cancer. Thetradtional concept of 6 months about liver cancer course should be renewed and the naturalcourse of hepatocellular carcinoma should be considered in estimating effect of anticancertherapy.
出处
《肝胆外科杂志》
1997年第4期236-238,共3页
Journal of Hepatobiliary Surgery
