摘要
目的探讨应用MSCT对肝细胞癌患者采用奥沙利铂+5-氟尿嘧啶+亚叶酸化疗方案治疗后近期疗效的评价作用。方法选择不能手术切除的病理组织学证实的原发性肝细胞癌或肝细胞癌术后多发转移患者6例,采用奥沙利铂+5-氟尿嘧啶+亚叶酸化疗方案治疗,化疗前后用MSCT检查确定靶病灶,靶病灶化疗前病灶大小作为基础值(x0),化疗后病灶大小作为观察值(y1),依据肿瘤生长的动力学数学模型y2(x)=X_02^(t/3td),计算每例患者基础值在观察期间内应增长值(y2)。结果化疗前后的MSCT检查,靶病灶均能一一对应,化疗前后靶病灶大小的实际测量数值和理论计算数值的统计学检验差别有统计学意义(P<0.05)。结论此化疗方案对抑制肿瘤生长速度有一定的作用,MSCT可作为评价肝细胞癌化疗疗效的一个较客观的手段。
Objective To study the value of MSCT in evaluating the recent curative effect of hepatocellular carcinoma （HCC） after the chemotherapy with Oxaliplatin combined with 5-FU and Folinic Acid. Methods 6 cases with HCC or post hepatectomy metastasis HCC confirmed by pathohistology underwent chemotherapy with Oxaliplatin combined with 5-FU and Folinic Acid. MultiSpiral Computed Tomography was used to determine the target lesions before and after the chemotherapy, The size of the target lesions before the chemotherapy was refer as the basic value （x0）, and that after the chemotherapy was regarded as the observed value （yl）. The theoretic value was obtained based on tumor growth dynamics mathematic model y2（x）=X02^v3td. Results Before and after the first chemotherapy or between the consecutive chemotherapy cycles, the target lesions could be follow-up one by one with MSCT. There was significant statistical difference between observed increase size and theoretical increase size, P = 0.0442. Conclusion Tumor growth velocity can be effectively controlled with this chemotherapy plan, and MSCT may used to be an objective tool to evaluate the recent curative effect of chemotherapy on hepatocellular carcinoma.
出处
《影像诊断与介入放射学》
2009年第1期23-24,共2页
Diagnostic Imaging & Interventional Radiology
关键词
肝细胞癌
化疗
MSCT
Hepatocellular carcinoma
Chemotherapy
MSCT
