摘要
目的：研究７－氯苄基四氢巴马汀对离体大鼠心肌缺血再灌损伤的影响。方法：利用Ｌａｎｇｅｎｄｏｒｆ大鼠心脏，结扎冠状动脉前降支（ＬＡＤ），缺血１０ｍｉｎ后，再灌注２０ｍｉｎ，造成缺血再灌损伤模型。结果：７－氯苄基四氢巴马汀（７－ｃｈｌｏｒＢＴＨＰ）可明显减慢心率，消除再灌注引起的心室纤颤，明显缩短心律失常持续时间，并能抑制离体大鼠心肌缺血、复灌时磷酸肌酸激酶（ＣＰＫ）及乳酸脱氢酶（ＬＤＨ）释放增加。结论：７－ｃｈｌｏｒＢＴＨＰ具有抗离体大鼠再灌注心律失常作用，对缺血再灌注损伤心肌有保护作用，其作用机制可能与其减慢心率，减少缺血复灌时心肌酶释放有关。
S AIM: To study the effects 7 chlor BTHP on ischemia reperfusion in isolated rat heart. METHODS: The ischemia reperfusion model was performed with left anterior descending(LAD) occlusion and reperfusion in langendorff rat heart. RESULTS: 7 chlor BTHP (10 μmol·L -1 ) abolished ventricular fibrillation (VF), significantly shorten duration of arrhythmias, slowed down heart rate, obviously decreased the release of myocardial enzyme creatine phispokinase (CPK) and lactate dehydrogenase (LDH). CONCLUSIONS: 7 chlor BTHP could protect myocardium against ischemic reperfused damage and the mechanism of protection was associated with decreasing heart rate of isolated heart and decreasing the release of myocardial enzyme.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1997年第3期227-229,共3页
Chinese Pharmacological Bulletin
基金
国家自然科学基金
