摘要
目的：观察前胡丙素（Ｐｒａ－Ｃ）对两种高血压模型大鼠尾动脉的钙拮抗作用。方法：采用两种高血压模型大鼠离体血管功能实验方法。结果：Ｐｒａ－Ｃ对氯化钾除极化所致正常、ＤＯＣＡ－ｓａｌｔ型、肾血管型高血压大鼠尾动脉呈非竞争性拮抗作用，其ｐＤ′２分别为４．６４、４．７７和５．２７，ＩＣ５０分别为１６．８８、１４．３７、６．４３μｍｏｌ·Ｌ－１，Ｐｒａ－Ｃ明显抑制５－ＨＴ所致正常、ＤＯＣＡ－ｓａｌｔ型、肾血管型高血压大鼠尾动脉慢速收缩反应，其中对肾血管型高血压大鼠的抑制作用较强，而对５－ＨＴ所致３组大鼠尾动脉的快速反应均无抑制作用。结论：Ｐｒａ－Ｃ对肾血管型高血压大鼠尾动脉的钙拮抗作用强于ＤＯＣＡ－ｓａｌｔ型高血压大鼠和正常大鼠，可能与两种高血压大鼠模型高血压形成机制不同有关。
AIM: To observe the calcium antagonistic effects of praeruptorin C(Pra C) on tail artery in two models of hypertensive rats. METHODS: The isometric tension of tail artery rings from two models of hypertensive rats were measured by a forcedisplacement transducer using experimental method of isolated blood vessel function. RESULTS:In the isolated tail artery of normotensive, DOCA salt hypertensive and renovascular hypertensive rats, Pra C was shown to inhibit the contraction induced by potassium depolarization and shifted the concentration response curve nonparallely to the right. The pD′ 2 values were found to be 4 64, 4 77 and 5 27 with IC 50 values of 16 88, 14 37 and 6 43 μmol·L -1 respectively. Pra C significantly inhibited extracellular calcium influx contractions but not inhibited intracellular calcium release contractions induced by serotonin in normotensive, DOCA salt hypertensive and renovascular hypertensive rats. CONCLUSIONS: The calcium antagonistic effects of Pra C in renovascular hypertensive rats is greater than that in DOCA salt hypertensive rats and normotensive rats, and it is probably related to different mechanisms of two models of hypertensive rats.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1997年第3期216-219,共4页
Chinese Pharmacological Bulletin
关键词
前胡丙素
高血压
肾血管型
细胞外钙
中药学
praeruptorin C
DOCA salt hypertensive rats
renovascular hypertensive rats
extracellular calcium
