摘要
以兔离体肺动脉环为研究对象，观察到前胡水煎剂及其石油醚提取物具有舒张肺动脉及降低肺动脉环对去甲肾上腺素和氯化钾所致收缩的反应性；其中石油醚提取物还能使去甲肾上腺素收缩肺动脉的量效曲线呈非平行右移，且最大反应降低，PD’2＝4．73±0．43。
Qian Hu is the roots of Peucedanum praeruptorum Dunn. The object of the present paper was to determine the effects of water extract (QH-I) and petroleum ether extract (QH-M) of Qian Hu on smooth muscle contractility of isolated rabbit pulmonary artery rings. QH-I and QH-M antagonized pulmonary artery rings conlraction elicited by NE as well as KCl.QH-I and QH-M caused relaxation of rabbit pulmonary artery rings precontracted with NE as well as KCl. The contraction dose-response curves of pulmonary artery rings with NE were shifted to the right and the maximal contraction response were inhibited 73.1 ±8.0% and 43 .6± 4.2% by 1 .6 × 10-5% and 8.0 × 10-5%, QH-M, pD'2 = 4.72 ±0.43. These results indicate that Qian Hu may relax pulmonary artery smooth muscle directly as a Ca2+ antagonist
出处
《中草药》
CAS
CSCD
北大核心
1994年第3期137-139,共3页
Chinese Traditional and Herbal Drugs
