摘要
目的探讨白细胞介素-6(IL-6)基因启动子区域-174G/C基因多态性与中国北方汉族人急性早幼粒细胞白血病(APL)的相关性。方法采用序列特异性引物聚合酶链反应(PCR-SSP)技术,检测20例APL患者组和90例正常对照组IL-6基因多态性。结果IL-6基因-174G/G基因型频率和G等位基因频率在两组人群中的分布差异有统计学意义(χ2=10.936,P<0.05,RR=1.525),G等位基因携带者患APL的风险是C等位基因的1.37倍(χ2=16.09,P<0.001,RR=1.37)。结论IL-6基因-174G/G基因型多态性与APL的发病具有相关性,其中G等位基因可能是我国北方汉族人APL发病的遗传易感性基因,携带G等位基因的个体可能通过促进IL-6的高度表达进而增加APL的发病风险。
Objective： To study the relationship between interleukin- 6 （IL- 6） gene promoter- 174G/C polymorphism and acute promyelocyti leukemia （APL） in Heilongjiang. Methods： The polymorphisms of IL-6 gene were analyzed by sequence specific primers polymerase chain reaction （PCR - SSP） methods in 20 patients with APL and 90 healthy controls. Results： The IL -6 gene - 174G/G polymorphism was significantly different between APL group and control group （ P 〈 0. 05 ） . The relative risk of ovary cancer of G allele was 1.37 times of the C allele （OR = 1.37）. Conclusion： IL-6 gene -174 G/G polymorphism was associated with APL, and G allele may be a risk factor for APL , in which the IL- 6 C allele carriers may have increase risk by enhancing the IL -6.
出处
《中国优生与遗传杂志》
2008年第2期41-42,共2页
Chinese Journal of Birth Health & Heredity
关键词
APL
白细胞介素-6
基因多态性
Acute promyelocyti leukemia
Interleukin - 6
Gene polymorphism
