摘要
自身免疫性疾病系由于机体免疫系统失衡,产生针对自身组织的免疫应答并导致自身组织、器官损害的一类疾病。调节性T淋巴细胞(Regulatory Tcell,Treg)具有免疫应答低下和免疫抑制特性,在维持机体免疫耐受和免疫应答稳态方面具有非常重要的作用,Treg的异常与多种自身免疫性疾病有关[1]。Foxp3特异性表达于CD4+CD25+Treg细胞,与其发育、成熟以及抑制功能关系密切。本文拟就Foxp3基因的研究进展及与多种自身免疫性疾病的关系作一综述。
Autoimmune Diseases are disorders caused by immune reactions against self-organs, as results of pathological imbalance of the immune system. New evidences indicates that regulatory T cells （Treg）, characterized by immune anergy and immune suppression, have play critical roles in containing immune tolerance, immune response, and homeostasis. The expression of Foxp3, mainly in Treg cells, is thought to be the major factors determining the immune regulative function of Treg. Decreased expression or dysfunction of Foxp3 has been found in IPEX syndrome, experimental autoimmune encephalomyelitis, diabetes mellitus, and other autoimmune diseases. In this article, we reviewed the recent progresses in researches of gene Foxp3 and its role in some autoimmune disease.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2008年第1期111-113,115,共4页
Immunological Journal
