摘要
目的:观察环氧合酶-2(cyclooxygenase-2,COX-2)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在子宫内膜异位症(EMs)中的表达,并探讨其在子宫内膜异位症发病机制中的作用。方法:利用免疫组化法检测COX-2和VEGF在35例EMs的异位内膜及在位内膜组织、35例正常子宫内膜组织中的表达。结果:①COX-2及VEGF在异位内膜的表达显著高于在位内膜和正常子宫内膜(P均<0.05)。而COX-2及VEGF在EMs在位内膜的表达显著高于正常子宫内膜(P均<0.05)。②EMs的异位内膜、在位内膜中COX-2和VEGF的表达之间有显著相关性(r=0.711;r=0.676,P均<0.01)。③COX-2和VEGF在EMs未孕与已孕患者异位内膜、在位内膜中的表达均未发现有统计学差异(P均>0.05)。结论:COX-2和VEGF在子宫内膜异位症的发生、发展中起重要作用。
Objective：To observe the expression of cyclooxygenase-2 （COX-2） and vascular endothelial growth factor （VEGF） in endometriosis, and to explore their possible role in the pathogenesis of endemetriosis. Methods： Expression of COX-2 and VEGF in 35 normal endornotrium as well as 35 ectopic endometrium and eutopic endometrium in endomdtriosis（There are 16 nonfertile patients and 19 patients who had childbearing history） were detected by immunohistochemistry, and the data was analyzed with SPSS11.0 statistical software. Results：①The expression level of COX-2 and VEGF in the ectopic endometriotic tissues was significantly higher than those in the eutopic endometrium and normal endometrium （ P 〈0.05）. And the expression level of both COX-2 and VEGF in the eutopic endometrium was significantly higher than that in normal endometrium （P〈0.05）. ②There was significantly relativity between the expression of COX-2 and VEGF both in the ectopic endometriotic tissues and eutopic endometrium（r =0.711 and r =0.676, P〈0.01）. ③ In the ectopic and eutopic endometriotic tissues, there was no statistical difference in the expression level of COX-2 and VEGF between the norffertile patients and the patients with childbearing history （ P 〉 0.05） .Conclusions： Both COX-2 and VEGF contriouted to the pathogenesis of endometriosis. This study would provide the base theory for clinic and search new target for the treatment of endometriosis.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2007年第11期662-664,共3页
Journal of Practical Obstetrics and Gynecology
基金
山东省自然科学基金项目(编号Y2003C01)
