摘要
目的研究流感大流行阶段应急接种人用禽流感疫苗不良事件监测的有效模式。方法以季节性流感疫苗模拟人用禽流感疫苗,在北京、江苏选取6个门诊接种共1218例,采用主动监测与被动监测相结合的方法开展集中接种疫苗后不良事件监测研究。结果收集不良事件报告36例;成人组报告数量最多,老年组报告数量最少;北京、江苏农村被动监测门诊均没有自愿报告;不良事件多为一般反应;各级疾病预防控制中心与药品不良反应监测机构建立了信息沟通交流机制。结论主动与被动相结合的监测模式,重点开展农村宣传教育活动,以及尽快建立各级疾病预防控制中心与药品不良反应监测机构的常规工作交流机制,均将促进应急状态下疫苗不良事件监测工作的开展。
Objective To research the effective adverse event following immunization （AEFI） monitoring pattern of pandemic human influenza vaccines during an influenza pandemic, Methods Using the influenza vaccine took place the pandemic human influenza vaccine, we implement the AEFI monitoring research with the active and passive methods in 1 218 people of six hospital from Beijing and Jiangsu. Results We received 36 reports. The reports of adults group were the most and the reports of elder group were the least. There were no reports in Beijing and Jiangsu country hospitals. Most of the adverse events are common. It is established the communication mechanism between the Control Disease Center （CDC） and Adverse Drug Reaction （ADR） Monitoring Center at all the lev- el. Conclusion Using active and passive methods, propagandizing in countryside people and establishing the daily work communication mechanism between CDC and ADR Center will promote AEFI monitoring in urgency situation.
出处
《中国药物警戒》
2007年第6期328-331,共4页
Chinese Journal of Pharmacovigilance
基金
科技部课题资金资助项目(2004BA519A74)
关键词
流感疫苗
不良事件
监测
influenza vaccine
adverse event
monitoring
