摘要
手性(硫)脲衍生物是各种亲核试剂对亚胺、醛、缺电子烯烃加成反应的非常有效的有机催化剂之一,已成功应用于对映选择性催化Strecker反应、Michael加成反应、Mannich反应、Baylis-Hillman反应、Henry反应等一系列重要的有机合成反应.手性(硫)脲衍生物具有催化活性高、对映选择性和功能基相容性好、易于制备和修饰、适用范围广等优点,成为近年来研究较多的不对称反应有机催化剂.对手性(硫)脲衍生物在有机催化不对称合成中的应用研究进展进行了评述.
Chiral （thio）urea derivatives are very effective organocatalysts for the nuclephilic addition reactions of imines, aldehydes, electron-deficient olefins, etc. They have been successfully applied in varieties of enantioselective organic reactions, such as asymmetric Strecker, Michael addition, Mannich, Baylis-Hillman, Acyl-Pictet-Spengler and Henry reactions as well as the dynamic kinetic resolution. Chiral （thio）urea derivatives are rapidly emerging as versatile, high catalytic active, low catalyst loading, excellent enantioselective, high functional group tolerant, ease of prepared/modified organocatalyst for the promotion of a wide range of synthetically useful asymmetric processes. The application of chiral （thio）urea derivatives in asymmetric organocatalysis is reviewed in this paper.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2007年第12期1491-1501,共11页
Chinese Journal of Organic Chemistry
基金
河北农业大学非生命学科和新兴学科科研发展基金(No.070015)资助项目.
