摘要
将硫脲衍生物用于有机催化蒽酮和β-硝基烯烃的不对称Michael加成反应.考察溶剂、温度及催化剂用量等对反应催化性能的影响.结果表明,最佳催化条件为5%(摩尔百分数)催化剂1f,二氯甲烷为溶剂,室温反应.得到了80%~97%的化学产率和最高达99%ee的对映选择性.
The（ thio） urea derivatives as organocatalysts were applied in asymmetric Michael addition reaction of anthrone with different nitroalkenes. The effect of solvent,temperature and catalyst loading ammount were investigated. The optimized conditions were confirmed to include CH2Cl2 as the solvent with a 5% loading of catalyst 1 fatrt.The desired products were obtained in 80% ~ 97% yield with up to 99% ee.
作者
王黎明
陈哲
赵美君
金瑛
WANG Li-ming;CHEN Zhe;ZHAO Mei-jun;JIN Ying(Department of Pharmacy, Jilin Medical University, Jilin 132013, China)
出处
《分子催化》
EI
CAS
CSCD
北大核心
2018年第2期187-193,共7页
Journal of Molecular Catalysis(China)
基金
国家自然科学基金(21102055)
吉林省教育厅"十三五"科学技术项目(JJKH20170409KJ)
吉林省卫生厅创新项目(2017J104)资助
大学生创新创业训练计划项目(201713743010)资助~~
