摘要
目的:探讨不同亚型注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)患者静息态脑功能磁共振的特点。方法:对符合DSM-Ⅳ诊断标准的6名混合型(ADHD-C)、9名注意缺陷型(ADHD-I)ADHD患者及15名正常对照进行静息态的功能磁共振扫描,采用局部一致性(regional homogeneity,ReHo)作为测量指标,探讨ADHD两种亚型之间以及ADHD与正常对照之间脑功能的差异。结果:经多重比较校正发现,三组的ReHo值在双侧额叶、右楔叶及右侧颞下回的差异均有统计学意义(P<0.05);与正常对照相比,ADHD-C左侧额叶及右侧颞下回的ReHo值降低,ADHD-I双侧额叶、双侧颞叶、右侧小脑的ReHo值降低,双侧枕叶及右侧顶下叶的ReHo值增高;两组ADHD患者之间的静息态脑功能未见明显差异。结论:与正常对照相比,ADHD患者的基线状态脑功能存在异常;两种亚型ADHD患者之间的基线状态脑功能无明显区别。
Objective： To study the differences of brain functions between children with attention deficit hyperactivity disorder （ADHD） predominantly inattentive （ADHD-I） and combined （ ADHD-C ） subtypes in resting state using functional magnetic resonance imaging （fMRI）. Methods： A newly reported regional homogeneity （ReHo） approach was used to analyze blood oxygen level-dependent fMRI （BOLD- fMRI） data in resting state among 6 ADHD-C, 9 ADHD-I and 15 normal control boys. Results： The brain regions showing differences among the three groups included bilateral frontal lobe, right cuneus and right inferior temporal gyms. Compared with the normal controls, ADHD-C showed decreased ReHo in left frontal lobe and right inferior temporal gyrus, ADHD-I showed decreased ReHo in bilateral frontal and temporal lobe and right cerebellum and increased ReHo in bilateral occipital lobe and right inferior parietal gyms. There were no brain regions showing different ReHo between ADHD-C and ADHD-I. Conclusion： Although both ADHD-C and ADHD-I showed abnormal neural activity in resting state compared with the normal controls, there were no differences for brain functions in resting state between ADHD-C and ADHD-I.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2007年第3期261-265,共5页
Journal of Peking University:Health Sciences
基金
卫生部临床学科重点项目(2004-468)
北京市科技计划项目(Y0204003040831)
科技部攻关项目(2004BA720A20)基金资助~~
关键词
注意力缺陷障碍伴多动
磁共振成像
脑
Attention deficit disorder with hyperactivity
Magnetic resonance imaging
Brain
