摘要
支气管哮喘（哮喘）发病的重要基础是辅助性T细胞（T helper cell，Th）两种亚型Th1和Th2细胞组成的比例及功能失衡。CpG DNA能抑制嗜酸粒细胞（eosinophils，EOS）的气道浸润，抑制气道变应性炎症，使Th2型细胞因子白介素4（IL-4）产生减少，并诱导Th1型细胞因子白介素12（IL-12）和7干扰素（IFN-γ）产生，诱导Th1反应，下调Th2反应，使Th2反应向Thl反应转变，进而使Th1／Th2细胞比例和功能达到平衡的状态，在哮喘治疗中具有重要的意义。
Nosogenic foundation of bronchial asthma（asthma） is the constitutive ratio and function imbalance of Th1, Th2 which are the subgroups of T helper cells. CpG DNA can inhibit airway from eosinophile granulocyte infiltration and blanket airway allergy inflammation. Intereleukin 4 （IL-4） of Th2 cytokine was decreased by CpG DNA. Interleukin 12（IL-12） and interferon gamma（IFN-γ） of Th1 cytokine were increased by CpG DNA. CpG DNA can down regulate Th2 but induce Th1 response, which can also shift the Th2 responses substantially toward Th1 and modulate the Th1/Th2 immune response balance. CpG DNA has significant meaning in cure of asthma.
出处
《国际呼吸杂志》
2007年第22期1696-1699,共4页
International Journal of Respiration
