摘要
探讨胃癌组织中IL-4和IL-6的表达水平与临床病理特征及预后的关系。方法：收集山东大学附属省立医院2011年8月～2012年4月42例胃癌患者的癌组织标本,使用RT-PCR检测IL-4和IL-6的mRNA表达水平,分析IL-4和IL-6的表达水平与胃癌临床病理资料和预后的关系。结果：胃癌组织中IL-4呈阳性表达（27/42,64.3%）,癌组织中IL-4的表达高于癌旁组织和正常组织,癌旁组织中IL-4表达亦高于正常组织。胃癌组织中IL-6呈阳性表达（30/42,71.4%）,癌组织中IL-6的表达高于癌旁组织和正常组织,癌旁组织中IL-6表达与正常组织相比差异无统计学意义（P〉0.05）。IL-4阳性表达的患者生存期明显低于IL-4阴性表达的患者;IL-6阳性表达的患者复发转移率多于IL-6阴性表达的患者。结论：IL-4以及IL-6在胃癌组织中表达明显升高,IL-4、IL-6有望成为判断胃癌预后的依据。
Objective： To detect IL-4 and IL-6 exprssion levels in gastirc cancer tissues, andanalyze the relationship of clinical prognosis. Methods： We collected the total RNA of carcinoma tissue samples. And we detected IL-4 and IL-6 mRNA expression level. Results： 64.3% （27/42）of patients had IL-4 positive expressions in gastric cancer tissues. The expression of IL-4 in the cancer tissue is significantly higher than that of normal tissue. 71.4% （30/42） of patients had IL-6 positive expression in gastric cancer tissue. The expression of IL-6 in the cancer tissue expressed no significant statistical difference compared with normal tissue. The survival time of patients with IL-4 positive expression are significantly lower than whom with IL-4 negative expression. The sur- vival time of patients with IL-6 positive expression are significantly lower than whom with IL-6 negative expression. Conclusion： It is significantly increased of IL-4 and IL-6 expressions in gastric cancer tissues. The marker of IL-4 and IL-6 is expected to be diagnostic factors of gastric cancer patients in the clinical tumor prevention and treatment.
出处
《中国现代普通外科进展》
CAS
2016年第6期451-454,共4页
Chinese Journal of Current Advances in General Surgery
关键词
胃肿瘤
白介素4
白介素6
预后
Gastric cancer
Interleukin 4
Interleukin 6
Cytokines
