摘要
目的探讨兔肾动脉狭窄模型的超声造影肾脏血流灌注模式。方法对10只实验兔递进性钳夹左肾动脉主干,钳夹程度分四级:0级-正常;Ⅰ级-钳夹动脉主干1/3;Ⅱ级-钳夹动脉主干2/3;Ⅲ级-完全钳夹。应用实时超声造影匹配成像技术行超声造影检查,动态观察各钳夹级别狭窄侧肾脏血流灌注。对各钳夹级别肾脏皮质及段间动脉部位进行量化分析,提供以下指标:曲线下面积、峰值强度、开始增强时间、曲线上升斜率。分析上述指标在不同程度肾动脉狭窄模型中的变化规律。结果①肾脏血流灌注增强模式:肾段间动脉、叶间动脉、肾皮质、肾髓质依次增强。随钳夹程度递进,肾脏开始增强时间逐渐延迟,增强程度逐渐减弱。肾动脉完全闭塞时,注射造影剂前后肾脏回声无明显改变。②超声造影时间-强度定量分析:随钳夹级别的递进,皮质和段间动脉取样,开始增强时间逐渐延迟,曲线下面积、峰值强度呈递减趋势。曲线上升斜率Ⅱ级组低于0、Ⅰ级组,0级组与Ⅰ级组无差异。结论超声造影增强模式对筛查肾动脉狭窄有一定价值;超声造影定量分析有助于评价不同程度肾动脉狭窄时缺血肾血流灌注。
Objective To study the renal perfusion flow in Renal Artery Stenosis （RAS） model using contrast-enhanced Ultrasound. Methods The left renal arteries of 10 rabbits were progressively ligated at several levels, including 0-normal, Ⅰ-ligated 1/3 of the artery, Ⅱ- ligated 2/3 of the artery,Ⅲ-ligated the artery completely. Renal perfusion flow was evaluated at every level using contrast tuned imaging gray scale ultrasound. Wash-in/Wash-out software was used to analyze the hemodynamic parameters （ET： time to enhancement, PSI： peak signal intensity, AUC： area under curve） on cortex and segmental artery. Results ①Renal segmental arteries, interlobar arteries, cortex, medulla were enhanced by turns. After left renal artery was ligated, ET was delayed, enhancement intensity was weaken. At ligated completely, renals were not enhanced. ②As renal artery was ligated gradually, ET was delayed, AUC and PSI were lower, ascending slope in level Ⅱwas lower than level 0 andⅠ. Conclusion The ultrasound enhancement pattern and quantitative analysis of RAS are helpful to evaluate the perfusion flow of renal ischemia.
出处
《中国医学影像技术》
CSCD
北大核心
2007年第10期1449-1452,共4页
Chinese Journal of Medical Imaging Technology
基金
山西省自然科学基金资助(2006011120)。
关键词
兔
肾
动脉狭窄
超声造影
Rabbit
Kidney
Artery stenosis
Contrast-enhanced ultrasound
