摘要
目的 利用经外周静脉团注声学造影剂FX5 30时肾能量图的动态变化 ,提取其中的相关参数进行再次参数成像 ,构建肾血流灌注功能图。方法 ①建立VX2 肿瘤模型。②建立急性肾动脉狭窄模型 :钳夹肾动脉主干 ,以银夹递进性钳夹肾动脉。③VX2 肿瘤模型制作后每隔 1周对肿瘤种植部位进行造影观察。在肾动脉狭窄模型中对每一级别狭窄分别进行造影观察 ,造影过程均采用心电门控 ,利用计算机采集造影动态图像。④对采集到的动态图像进行后处理 ,利用特别设计的软件进行功能图构建 ,分别利用曲线下面积、半降时间、下降斜率等 3个参数进行功能图重建 ,分析它们的异同及意义。结果 ①灌注功能图 :把功能性指标信息直观化 ,不但能反映灌注的功能信息及其分布 ,而且能清晰、直观地评价肿瘤血供的动态变化以及弥漫性肾实质缺血引起的灌注功能的改变。②以曲线下面积构建的功能图质量最好 ,无伪像及彩色镶嵌现象。以半降时间及下降斜率构建的功能图存在较严重的伪像、彩色镶嵌现象及失真。结论 灌注功能图是一项新的成像技术 ,具有广泛的应用价值 ,进一步改善成像方法和手段将有更深入的研究价值。
Objective To present a new imaging technique,functional image,linking the timedependent changes in the intensity of the power Doppler image produced by the microbubbles. Methods ①The renal VX 2 model of the rabbit was made in 10 rabbits. ②The renal artery stenosis model was made in 5 rabbits progressively in four level. Each image was obtained from the end diastole of the cardiocycle using ECG triggring.Using the specially designed software, a time intensity curve was derived from the consequential power Dopper images for each of all pixels within the images. Three parameters,including area under the curve, half time of the decrement of the peak, and decrease slope, were obtained from the time intensity curve. Finally, the function image was constructed using above three parameter.Results ①The functional image could demonstrate the flow perfusion static of the organ or tumor clearly and directly. ②Among the parameters of constructing the functional image, the area nder the curve functional image was the ideal and best in which could be avoided the false element and mosaic. But the halftime of the decrement of the peak, decrease slope was not satisfied with the mosaic and false element.Conclusions The perfusion functional image is new technique to evaluate the perfusion function of the organ and has the wide applicational value.
出处
《中华超声影像学杂志》
CSCD
2000年第6期370-373,共4页
Chinese Journal of Ultrasonography
关键词
超声检查
造影剂
肾
灌注功能图
Ultrasonography
Contrast media
Kidney
Functional image of flow
