摘要
为明确糖尿病病人血清肌酸激酶(CK)变化的意义,采用紫外分光光度法检测了110例糖尿病(DM)患者血清CK及其它指标。结果:1.糖尿病组血清CK值明显低于对照组,其中有血管病变组(Ⅰ组)又明显低于无血管病变组(Ⅱ组),P<0.05或P<0.01。血清镁离子(Mg)Ⅰ组明显低于Ⅱ组及对照纽,后两者无明显差异。2.相关分析表明,CK与病程和HbAlc成负相关(P<0.05),与Mg成正相关(P<0.01),而与空腹血清INS、C-P和年龄无相关性(P>0.05)。结论:DM患者Mg离子含量下降,CK活性降低,并随病情的进展而加重。血清CK的检测有助于判断治疗效果以及预后。
The creatine kinase (CK ) of muscle tissues is related to the development of vascular complication of diabetes mellitus(DM) patients. Serum CK and other biochemical indices of 110 cases of DM patients were assayed by biochemical methods. The results showed that for those patients who were accompanied by vascular complications serum CK and magnesium (Mg) were reduced obviously compared with patients who had not vascular complications. Multiple regression analyses demonstrated that CK was correlated positively with Mg, while it was negatively correlated with glyco-hemoglobin and disease duration. The results suggested that the reduction of serum CK and Mg was involved in the initiation and development of DM complications. The measurement of CK was contributed to evaluate the disease severity and therapeutic effect.
出处
《天津医药》
CAS
1997年第6期334-336,共3页
Tianjin Medical Journal
关键词
糖尿病
肌酸激酶
血管病
diabetes mellltus creatine kinase diabetic angiopathy
